In this talk, I begin wtih the nonlinear Schroedinger/Gross-Pitaevskii equations (NLSE/GPE) for modeling Bose-Einstein condensation (BEC), nonlinear optics, quantum physics and chemistry, etc., and review some dynamical properties of NLSE/GPE including conserved quantities, dispersion relation, center-of-mass dynamics,soliton solutions and semiclassical limits. Different numerical methods will be presented including finite different time domain (FDTD) methods and time-splitting spectral method, and their error estimates and comparison will be discussed. Extensions to NLSE/GPE with an angular momentum rotation term and/or non-local dipole-dipole interaction as well as multi-component will be presented. Finally, applications to soliton interactions, collapse and explosion of BEC, quantum transport and quantized vortex interaction will be investigated.